Acted opposite Gerard Depardieu in French television adaptation of "Les Misérables"; English language version aired in U.S. 2001 on Fox Family Channel
Broadway debut, "Death of a Salesman," playing Biff to Dustin Hoffman's Willy Loman
Directed and designed sound for the revival of Lanford Wilson's "Balm in Gilead" at the Steppenwolf Theatre in Chicago and subsequently off-Broadway
Formed Smith-Malkovich Productions with Russell Smith
Featured in A&E miniseries "Napoleon"; received an Emmy nomination for Outstanding Supporting Actor in a Miniseries or a Movie
Made film debut as photojournalist in "The Killing Fields"
Made off-Broadway debut in Steppenwolf production of "True West," directed by Sinise (who also co-starred)
Played John Malkovich, a fictionalized version of himself, in Spike Jonze's witty and picaresque "Being John Malkovich"
Portrayed profligate seducer Gilbert Osmond in "The Portrait of a Lady," adapted from novel by Henry James
Stage directing debut, "The Rear Column," at the North Light Repertory Theatre, Evanston, IL
Adapted and directed the Steppenwolf production of Don DeLillo's "Libra," starring Laurie Metcalf and Alexis Arquette
Appeared in production of Sam Shepard's "Curse of the Starving Class" at Chicago's Goodman Theatre
Cast as King Galbatorix, a powerful Dragon Rider in "Eragon" a fantasy/adventure movie based on novel of same name
Cast as Reverend Briegleb in Clint Eastwood's "Changeling"
Co-starred in spy comedy feature "Johnny English"
Debuted as executive producer with "The Accidental Tourist"; did not act in film
First starring role in a feature, as journalist Nicholas Gage in Peter Yates' "Eleni"
Joined ensemble cast for Coen brothers' "Burn After Reading"
Offered an intriguing turn as the treacherous French aristocrat Valmont in "Dangerous Liaisons," helmed by Stephen Frears; on-set romance with co-star Michelle Pfieffer led to end of his marriage to Glenne Headly
Played dual roles of a nerdy scientist and a lookalike android in Susan Seidelman's "Making Mr. Right"
Played Herman J. Mankiewicz in HBO's "RKO 281," detailing the clash between Orson Welles and William Randolph Hearst over production and release of "Citizen Kane"
Played Lennie to Sinise's George in remake of "Of Mice and Men," directed by Sinise; had first essayed role in a Steppenwolf stage production many years earlier
Portrayed Austrian artist Gustav Klimt in Raoul Ruiz's "Klimt"
Portrayed film director F. W. Murnau in "Shadow of the Vampire," a fictionalized account of Murnau's filming of "Nosferatu," based on Bram Stoker's "Dracula"; screened at Cannes
Portrayed Unferth in Robert Zemeckis' big-budget film version of "Beowulf"
Reveled in scene-chewing role of Cyrus 'The Virus' Grissom in "Con Air"
Starred opposite Joan Allen in Broadway production "Burn This"
Teamed with director Bernardo Bertolucci for vividly atmospheric but torturously slow "The Sheltering Sky"
Appeared as sinister Kurtz in TNT movie presentation "Heart of Darkness," directed by Nicolas Roeg
Broadway directing debut, "Arms and the Man"; later assumed leading role, replacing Kevin Kline; production also featured then-wife Glenne Headly
Earned Best Supporting Actor Oscar nomination for his turn as a misanthropic blind man in Robert Benton's "Places in the Heart"
Formed Mr. Mudd production company with producers Lianne Halfon and Russell Smith
Made feature directorial debut with "Dancer Upstairs," a police thriller based on a novel by Nicholas Shakespeare
Received second Best Supporting Actor Oscar nomination as demented assassin Mitch Leary in "In the Line of Fire"
Returned to New York stage as the bombastic war veteran of Shepard's "States of Shock"
Staged "Hysteria" at Chicago's Steppenwolf Theater Company
Starred as Comandante John Walesa in Manoel de Oliveira's "Um Filme Falado/A Talking Picture"
Starred in TV adaptation of "True West" (aired on PBS' "American Playhouse")
Cast in Terry Zwigoff's adaptation of Daniel Clowes' comic story "Art School Confidential"
Co-starred with Josh Brolin and Megan Fox in "Jonah Hex"
Joined Chicago's Steppenwolf Theatre (founded 1974 by Gary Sinise), working on more than 50 productions during the years
Offered over-the-top performance as a Russian mobster in "Rounders," scripted by David Levien and Brian Koppelman
Portrayed Alan Conway in "Colour Me Kubrick," the true story of a man who posed as director Stanley Kubrick
Reprised stage role of Biff in CBS TV adaptation of "Death of a Salesman," starring Hoffman; received Emmy Award
Served as one of producers of "Ghost World"
TV-movie debut, "Word of Honor" (CBS)
Portrayed trainer Lucien Laurin in "Secretariat," based on horse that won U.S. Triple Crown in 1973
Appeared in Michael Bay's "Transformers: Dark of the Moon"
Joined Bruce Willis, Helen Mirren, and Morgan Freeman in action comedy "Red"
Appeared in zombie romance "Warm Bodies," starring Nicholas Hoult
Featured in "Red 2"