Cast as Velma Von Tussel in the remake of the John Water's film "Hairspray"
Co-starred with Jessica Lange in "A Thousand Acres"; a modern-day version of "King Lear" adapted from Jane Smiley's Pulitzer Prize-winning novel
Debut as executive producer (also acted), "One Fine Day"; also starred George Clooney
Downplayed her looks to portray a working-class waitress romanced by a short-order cook (Al Pacino) in "Frankie & Johnny"
Portrayed a lawyer fighting to help an autistic father (Sean Penn) retain custody of his daughter in "I Am Sam"
Portrayed a woman who murder's her boyfriend and has her daughter taken away in "White Oleander"; earned a SAG nomination for Best Supporting Actress
Received a Best Supporting Actress Oscar nomination as the married Madame de Tourval in Stephen Frears' "Dangerous Liaisons"
Was a regular on the Aaron Spelling-produced series "B.A.D. Cats" (ABC)
Earned Best Actress Oscar nomination as the chanteuse Susie Diamond in "The Fabulous Baker Boys"
Had box-office hit as former Marine-turned-teacher LouAnne Johnson in "Dangerous Minds"
Received second Best Actress Oscar nomination as a woman traveling to the funeral of President John F Kennedy in "Love Field"
Reportedly turned down the lead role of "Evita" in the film because she did not want to work on location
Teamed with Robert Redford as a rising TV newsreporter in "Up Close and Personal"
With producing partner Kate Guinzberg, formed first look deal with Orion Pictures
Reteamed with Jack Nicholson for "Wolf"
Took supporting role of the ghost of Peter Gallagher's wife in "To Gillian on Her 37th Birthday"; film written by David E. Kelley
TV acting debut in bit role on ABC's "Fantasy Island"
TV movie debut in "The Solitary Man" (CBS)
Co-starred as Tatiana in a film version of "A Mid Summer Night's Dream"
Co-starred with Harrison Ford in the Robert Zemeckis's thriller "What Lies Beneath"
Directed by her then-husband Peter Horton in the ABC TV-movie "One Too Many"
Feature film debut, "The Hollywood Knights"
Landed female lead in the film sequel "Grease 2"
Made NYC stage acting debut in "Twelfth Night"; performed in Central Park under the auspices of Joseph Papp's New York Shakespeare Festival
Made uncredited cameo appearance in an episode of "Picket Fences"; created by husband David E. Kelley
Played a widowed Mafia wife in Jonathan Demme's comedy "Married to the Mob"
Played the evil witch Laima in the fairy tale "Stardust," a feature based on the fantasy adventure novel by Neil Gaiman
Played title role in "Natica Jackson," an episode in the the three-part PBS series "Tales From the Hollywood Hills"; last major television acting role to date
Produced and starred in "The Deep End of the Ocean"
Provided a character voice for the DreamWorks animated film "The Prince of Egypt"
Re-teamed with director Stephen Frears for "Cheri"
Cast in the ensemble romantic comedy "New Year's Eve," directed by Garry Marshall
Co-starred with Johnny Depp in Tim Burton's remake of the gothic soap opera "Dark Shadows"
Starred alongside Chris Pine and Elizabeth Banks in the dramedy "People Like Us"
Co-starred with Robert De Niro in the mob comedy/thriller "The Family"
Made her MCU debut in "Ant-Man and the Wasp"
Returned to the MCU in "Avengers 4"
TV debut as regular on the short-lived ABC sitcom "Delta House," which was inspired by the feature film "Animal House"
First box-office hit, "The Witches of Eastwick"; co-starred with Jack Nicholson, Susan Sarandon and Cher
Earned critical notice, co-starring with Al Pacino in Brian De Palma's gangster classic "Scarface"
Received a star on the Hollywood Walk of Fame (August)
Won raves for her performance as Catwoman/Selina Kyle in "Batman Returns"; Tim Burton directed
Led the cast of New York-set drama "Where Is Kyra?"
Gave a devious turn in Darren Aronofsky's surreal mystery "Mother!"
Starred in Kenneth Branagh's "Murder on the Orient Express" remake