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The film was copyrighted once, on 21 December 1955, by three claiments: Paramount Pictures Corp., Hal B. Wallis and Joseph H. Hazen. Artists and Models was the second film made by Shirley MacLaine, who made her film debut in Alfred Hitchcock's The Trouble with Harry , but was the first film in which she was allowed to display the singing and dancing talents which had brought her to producer Hal B. Wallis's attention when he first saw her in The Pajama Game on Broadway. Hollywood Reporter news items report that another Broadway star, Gwen Verdon, had been sought for a role in Artists and Models by Wallis, probably the role of "Bessie Sparrowbush," which was played in the film by MacLaine. Artists and Models was also the first of two Martin and Lewis films to be directed by Frank Tashlin. Tashlin also directed the comedy team's final film, Hollywood or Bust .
According to the file on the film in the Paramount Collection at the AMPAS Library, Artists and Models was produced at the cost of $1,701,083, which was $103,083 over its allotted budget. Because of the budget overruns, a planned "The Bat Lady" musical production number was never filmed. While modern sources state that "The Bat Lady" musical number was filmed on the last day of shooting (3 May 1955), the breakdowns found in the Paramount Collection indicate the day in question was used to shoot the film's main title sequence. According to modern sources, Wallis blamed Lewis for the cost overruns on Artists and Models, claiming the comedian had "an ever-increasing tendency to meddle in other people's departments." Information found in the Paramount collection indicates that the Michael Davidson-Norman Lessing play Rockabye Baby, upon which Artists and Models is based, was never produced.
Swedish actress Anita Ekberg was loaned to Paramount by Batjac Productions for this film, after which Batjac failed to pick up the option on her contact, according to Hollywood Reporter. Ekberg was also featured in Hollywood or Bust. Hollywood Reporter news items include Terry Allen Rangno in the cast, but his appearance in the released film has not been confirmed. Dean Martin introduced the song "Innamorta" in Artists and Models, which become one of his signature songs. This film is unrelated to the 1937 Paramount film of the same name, though both featured the annual Artists and Models ball.