- Peter Sellers was cast in four roles, but experienced problems when trying to develop a Texas accent for Major T. J. "King" Kong. After Sellers coincidentally broke his leg, Kubrick was forced to find another actor. Convinced that nobody could have acted the part as well as Sellers, Kubrick decided to cast someone who naturally fit the role. Remembering his work on the western One-Eyed Jacks (1961), Kubrick cast 'Pickens, Slim' as Kong, the gung-ho hick pilot determined to drop his bombs at any cost. Pickens was never shown the script nor told it was a black comedy; ordered by Kubrick to play it straight, he played the role as if it were a serious drama - with amusing results.
- Sellers based Dr. Strangelove's strangled accent on the voice of Weegee, the famous German-born crime photographer of the 1950s whose name was given by New York police due to his uncanny ability to show up at murder scenes before they did. Sellers heard Weegee talking during an on-set visit and adopted his strange German accent for the title character.
- The photographic mural in General Ripper's office, presumably showing an aerial view of Burpelson AFB, is actually a view of Heathrow Airport, London.
- General Turgidson (George C. Scott) was not scripted to fall over in the war room when he gets excited, but when it happened, Kubrick decided it was in character, and left it in.
- In Terry Southern's script, Muffley has a bad cold. Peter Sellers played this up so hilariously that the cast kept breaking up during filming, but Kubrick then decided to make him a foil for everyone else's craziness instead, and re-shot the scenes with Sellers now playing the role straight.
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