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The film begins with a voice-over narration describing the Portuguese colony of Macao, off the coast of China, serves as a haven for smugglers, gamblers and pirates. Although a June 1950 Hollywood Reporter article states that Leonard Freeman was to begin his first assignment for Universal as an actor/writer/director with this film, he does not appear to have worked on the picture. Both Hollywood Reporter production charts and news items from June 1950 identify Teru Shimada as a cast member, but his appearance in the final film has not been confirmed. Other Hollywood Reporter news items include Su Tung Foo and Stapleton Kent in the cast and report that actress Carol Varga was "discovered" in Honolulu and cast without a screen test. Varga made her actual feature film debut in Universal's Up Front (see below), which was released before Smuggler's Island but shot a few months later. Her appearance in Smuggler's Island has not been confirmed. The Variety review notes that the film was shot on Macao.