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The latest in a series of unsolved murders connected with the Luxor Hotel in Berlin leads the authorities to believe that a criminal gang exists headed by someone believing himself to be a reincarnation of the famous Dr. Mabuse. When Henry Travers, an American millionaire, saves Marion Menil from an attempted suicide leap from the ledge of a hotel window, both become involved in the investigation. Commissioner Krauss, meanwhile, has two suspects for the Mabuse imitator: Jordan, supposedly a blind clairvoyant, and Mistelzweig, an insurance salesman. Marion falls in love with Travers and tries to save him from Mabuse's men, even though she had been hypnotized into tricking Travers out of his fortune. Krauss's men invade the hotel and unmask Jordan as the mastermind behind the scheme. A car chase ensues, during which Jordan is killed, and, although Marion is wounded by one of Mabuse's gunmen, she and Travers are rescued by an INTERPOL agent.